منابع مشابه
DNA replication in eukaryotic cells.
The maintenance of the eukaryotic genome requires precisely coordinated replication of the entire genome each time a cell divides. To achieve this coordination, eukaryotic cells use an ordered series of steps to form several key protein assemblies at origins of replication. Recent studies have identified many of the protein components of these complexes and the time during the cell cycle they a...
متن کاملMaking sense of eukaryotic DNA replication origins.
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA seque...
متن کاملStructural insights into eukaryotic DNA replication
THREE DNA POLYMERASES OF THE B FAMILY FUNCTION AT THE REPLICATION FORK IN EUKARYOTIC CELLS: DNA polymerases α, δ, and ε. DNA polymerase α, an heterotetramer composed of two primase subunits and two polymerase subunits, initiates replication. DNA polymerases δ and ε elongate the primers generated by pol α. The DNA polymerase from bacteriophage RB69 has served as a model for eukaryotic B family p...
متن کاملPolymerase Dynamics at the Eukaryotic DNA Replication
This review discusses recent insights in the roles of DNA polymerases (Pol) and in eukaryotic DNA replication. A growing body of evidence specifies Pol as the leading strand DNA polymerase and Pol as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mutator phenotype for certain m...
متن کاملEukaryotic DNA Replication Origins Reconciling Disparate Data
A new insight is revealed by Anglana et al. 128 kb of the single, primary (high frequency) oriGNA13. mary origin represses initiation at the secondary origins. Moreover, increasing the nucleotide pool by addition of DNA precursors to the culture medium reduces the frequency of initiation at secondary origins, whereas reducing the nucleotide pool by addition of hydroxyurea (a specific inhibitor ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2013
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a012963